BP104T - Pharmaceutical Inorganic Chemistry
Scope: This subject deals with the monographs of inorganic drugs and pharmaceuticals.
Objectives: Upon completion of course student shall be able to
- know the sources of impurities and methods to determine the impurities in inorganic drugs and pharmaceuticals
- understand the medicinal and pharmaceutical importance of inorganic compounds
UNIT-1
- Impurities in pharmaceutical substances: History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate
- General methods of preparation, assay for the compounds superscripted
with asterisk (*), properties and medicinal uses of inorganic compounds
belonging to the following classes
UNIT-2
- Acids, Bases and Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.
- Major extra and intracellular electrolytes: Functions of major physiological ions, Electrolytes used in the replacement therapy: Sodium
chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base balance. - Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc
eugenol cement.
UNIT-3
- Gastrointestinal agents
Acidifiers: Ammonium chloride* and Dil. HCl
Antacid: Ideal properties of antacids, combinations of antacids, Sodium 40 Bicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture
Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite
Antimicrobials: Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen peroxide*, Chlorinated lime*, Iodine and its preparations
UNIT-4
- Miscellaneous compounds
Expectorants: Potassium iodide, Ammonium chloride*.
Emetics: Copper sulphate*, Sodium potassium tartarate
Haematinics: Ferrous sulphate*, Ferrous gluconate
Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333
Astringents: Zinc Sulphate, Potash Alum
UNIT-5
Radiopharmaceuticals: Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations, Half life, radioisotopes and study of radio
isotopes – Sodium iodide I131, Storage conditions, precautions & pharmaceutical application of radioactive substances..